A number of Washington University in St. Louis (WashU) investigators have developed highly specialized, cutting-edge methods for manipulation and analysis of sleep and circadian function in humans and animals. While these methods exist outside the purview of the COBRAS Cores, we can connect interested investigators with these specific labs to support further collaboration. Specialized techniques available through affiliated labs include:
- 24-hour CSF sampling, protein kinetics with SILK: Brendan Lucey, Randall Bateman
- Ambulatory EEG monitoring with SleepProfiler: Brendan Lucey
- Closed-loop disruption of slow-wave sleep: Yo-El Ju
- Blood-based transcriptional biomarkers of circadian function: Yo-El Ju, Erik Musiek
- Drosophila models of sleep/circadian function: Paul Shaw, Paul Taghert
- Opto- and chemogenetic manipulation of sleep or arousal: David Holtzman, Aaron Norris
- Opto- and chemogenetic manipulation of circadian function: Geraldine Kress, Erik Herzog
- Molecular imaging of cellular circadian rhythms: Erik Herzog
- Long-term monitoring of sleep with implanted electrode arrays: Keith Hengen
- Cerebral microdialysis: John Cirrito, David Holtzman
- Circadian clock gene mutant mouse colonies: Erik Musiek, Jeff Haspel, Erik Herzog
- Bioinformatic analysis of circadian time-series and transcriptomic data: Michael Hughes