General Services Pricing
| Service | Time/Item | Member Price | Non-WU or Industry Price | Notes |
| Consultation | Per Hour | $100 | ** | The first hour is free for COBRAS members |
| Start-up Fee | Flat Rate per Year | $50 | ** |
Preclinical Core Pricing
| Service | Time/Item | Member Price | Non-WU or Industry Price | Notes |
| Technician Time | Per Hour | $35 | ** | |
| Cage | Per Cage, Per Day | $1 | ** | |
| Sensor (Infrared) | Per Cage, Per Day | $0.25 | ** | |
| Sensor (piezoelectric) | Per Cage, Per Day | $5 | ** | |
| Basic Data Analysis | Flat Rate | $100 | ** | |
| Advanced Data Analysis | Per Hour | $100 | ** | Required for Piezoelectric Sleep studies. |
**Contact COBRAS for pricing information
Preclinical Core Experiments with Package Pricing:
1. Typical Infrared Circadian Actigraphy Experiment: $1,220 (price for COBRAS Members)
This package provides infrared actigraphy for 12 mice x 21 days of monitoring (7 days 6am-6pm light:dark, 14 days constant conditions). It includes initial consultation, 1 hour/day of technician time, setup, sensor costs for 12 cages x 21 days, and standard data analysis. Data is analyzed using ClockLab software to assess multiple circadian parameters.
2. Typical Piezoelectric Sleep Monitoring Experiment: $851 (price for COBRAS Members)
This package provides 7 days of sleep monitoring for 8 mice using the SignalSolutions piezoelectric cage system in controlled-environment cabinets. It includes initial consultation, 1 hour/day of technician time, sensor costs x 7 days, setup, and advanced data analysis.
Many other experiment types are available, including altered light:dark cycles/”jetlag”, tissue harvest at circadian timepoints, and studies with various clock gene mutant mice. Sleep deprivation/fragmentation and sleep EEG studies can also be arranged through our collaborators.
Human Core Pricing
| Service | Time/Item | Member Price | Non- WU or Industry Price* | Notes |
| Polysomnograms (sleep studies) | ||||
| Polysomnogram Overnight# – attended | Per study | $480 | $600 | Space, equipment, and supplies are separately charged through CTRU |
| Polysomnogram Overnight# – unattended | Per study | $148 | $185 | Space, equipment, and supplies are separately charged through CTRU |
| Polysomnogram data scoring | Per hour of data | $9.25, minimum $20 per recording | $11.50, minimum $25 per recording | |
| Actigraphy | ||||
| Actigraphy study set-up | Flat Rate | $200 (overall study start-up fee will be discounted) | $250 | Includes consultation, instructions for Actigraph setup, download, and charging; instructions for data download and analysis. |
| Actigraphs (watches) | Per Watch Per Week | $5 | $6 | Philips-Respironics Actiwatch2. Lost actigraphs will be billed at $650 each. |
| Actigraphy docking & charging station and software | Per dock Per Week | $15 | $19 | Philips-Respironics Actiwatch2 docking station and Actiware |
| Actigraphy Technician | Per actigraph recording | $40 | $50 | For investigators who elect not to set up/charge/download own devices. |
| Actigraphy Scoring and Analysis | Per actigraph recording up to 15 days | $20 | $25 | Includes manual sleep scoring in Actiware and standard circadian variables in Clocklab. |
| Miscellaneous | ||||
| Registered Polysomnographic Technologist time | Per hour | $37 | $46 | |
| Funnels for saliva capture | Per unit | $1 | $1 |
*Additional overhead rate will be applied to industry-sponsored studies
#For staffing purposes, overnight studies must begin between 6pm-10pm, and end between 6am-8am.
Polysomnography Cost Details
The COBRAS Human Core currently provides polysomnography in the CTRU. Currently (FY22), CTRU costs (separately billed) are $250 for overnight space/nursing and $57 for equipment/supplies for investigator-initiated studies, for total $787 per attended polysomnogram.
If a study schedules two polysomnograms on the same night, the COBRAS Core cost may be divided between the two, i.e. $240 COBRAS Core + $250 space/nursing + $57 supplies = $547 total per study.
For industry-sponsored studies, CTRU costs are currently (FY22) estimated to be in the ~$1500 range for space, nursing, equipment, and supplies for an overnight polysomnogram, in addition to the COBRAS Core cost. Please contact the CTRU for detailed pricing.
Polysomnogram costs include scoring by a registered PSG technologist, basic reports, and export of data. Review and interpretation by a sleep medicine physician is not included.
Sample Basic Actigraphy Study for N=20 participants ($500 for COBRAS Members)
Actigraphy study set up and instruction ($200), 2 Actigraph watches x 10 weeks assuming 1-week recordings for each participant ($100), 1 docking/charging station x 10 weeks ($150). This assumes that the study team (not Core) will set up/download all actigraphs and perform own scoring/analysis.
Sample full-service actigraphy study for N=20 participants ($1500 for COBRAS Members)
Actigraphy study set up and instruction ($200), 2 Actigraph watches x 10 weeks assuming 1-week recordings for each participant ($100), Actigraphy technician x20 ($800), Actigraphy scoring and analysis x20 ($400). In this scenario, the Core will set up/download all actigraphs and perform own data scoring/analysis.
Salivary dim light melatonin measurement
Funnels to assist in collecting saliva by passive drool method are available at a bulk discounted rate through COBRAS. These funnels are custom-made to fit onto Salimetrics vials. One is required for each vial, and on average 5 are required for evening-bedtime hourly sampling per participant. Please contact the COBRAS Core for additional information on collection procedures, storage, and assay costs.