Alzheimer’s Disease/Neurodegeneration

Musiek ES, Morris JC. Possible Consequences of the Approval of a Disease-Modifying Therapy for Alzheimer Disease. JAMA neurology. 2020 Nov 30.

Smith SK, Musiek ES. Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseases. International Review of Neurobiology. 2020 Jul 10;154:393-412.

Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, Finn MB, Manis M, Geerling JC, Fuller PM, Lucey BP, Holtzman DM. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science. 2019 Feb 22;363(6429):880-884. doi: 10.1126/science.aav2546. Epub 2019 Jan 24.

Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci Transl Med. 2019 Jan 9;11(474):eaau6550. doi: 10.1126/scitranslmed.aau6550.

Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM. Slow wave sleep disruption increases cerebrospinal fluid amyloid-beta levels. Brain. 2017 Aug 1;140(8):2104-2111. doi: 10.1093/brain/awx148.

Ju YS, Zangrilli MA, Finn MB, Fagan AM, Holtzman DM. Obstructive sleep apnea treatment, slow wave activity, and amyloid-beta. Ann Neurol. 2019 Feb;85(2):291-295. doi: 10.1002/ana.25408. Epub 2019 Jan 17

Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM. Sleep quality and preclinical Alzheimer disease. JAMA Neurol. 2013 May;70(5):587-93. doi: 10.1001/jamaneurol.2013.2334.

Musiek ES, Holtzman DM. Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science. 2016 Nov 25;354(6315):1004-1008. doi: 10.1126/science.aah4968.

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009 Nov 13;326(5955):1005-7. doi: 10.1126/science.1180962. Epub 2009 Sep 24.

Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ, Holtzman DM. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer’s disease pathology.  Sci Transl Med. 2012 Sep 5;4(150):150ra122. doi: 10.1126/scitranslmed.3004291.

Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013 Dec;123(12):5389-400. doi: 10.1172/JCI70317. Epub 2013 Nov 25.

Barthélemy NR, Liu H, Lu W, Kotzbauer PT, Bateman RJ, Lucey BP. Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid.  Ann Neurol. 2020 May;87(5):700-709. doi: 10.1002/ana.25702. Epub 2020 Feb 27.

Lucey BP, Hicks TJ, McLeland JS, Toedebusch CD, Boyd J, Elbert DL, Patterson BW, Baty J, Morris JC, Ovod V, Mawuenyega KG, Bateman RJ. Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics. Ann Neurol. 2018 Jan;83(1):197-204. doi: 10.1002/ana.25117.

Lucey BP, Mawuenyega KG, Patterson BW, Elbert DL, Ovod V, Kasten T, Morris JC, Bateman RJ. Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System.  JAMA Neurol. 2017 Feb 1;74(2):207-215. doi: 10.1001/jamaneurol.2016.4202.

Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES. Circadian clock protein Rev-erbα regulates neuroinflammation. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5102-5107. doi: 10.1073/pnas.1812405116. Epub 2019 Feb 21.

Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES. Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med. 2018 Apr 2;215(4):1059-1068. doi: 10.1084/jem.20172347. Epub 2018 Jan 30.

Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS. Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol. 2018 May 1;75(5):582-590. doi: 10.1001/jamaneurol.2017.4719.

Anesthesiology/Perioperative

Guay CS, Labonte AK, Montana MC, Landsness EC, Lucey BP, Kafashan M, Haroutounian S, Avidan MS, Brown EN, Palanca BJ. Closed-Loop Acoustic Stimulation During Sedation with Dexmedetomidine (CLASS-D): Protocol for a Within-Subject, Crossover, Controlled, Interventional Trial with Healthy Volunteers. Nature and Science of Sleep. 2021;13:303.

Smith SK, Nguyen T, Labonte AK, Kafashan M, Hyche O, Guay CS, Wilson E, Chan CW, Luong A, Hickman LB, Fritz BA. Protocol for the Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) study: a prospective observational study of delirium in elderly cardiac surgical patients. BMJ Open. 2020 Dec 1;10(12):e044295.

Kafashan M, Hyche O, Nguyen T, Smith SK, Guay CS, Wilson E, Labonte AK, Guan MJ, Lucey BP, Ju YE, Palanca BJ. Perioperative sleep in geriatric cardiac surgical patients: a feasibility study using a wireless wearable device. British Journal of Anaesthesia. 2021 Apr 1:S0007-0912.

King CR, Fritz BA, Escallier K, Ju YS, Lin N, McKinnon S, Avidan MS, Palanca BJ. Association Between Preoperative Obstructive Sleep Apnea and Preoperative Positive Airway Pressure With Postoperative Intensive Care Unit Delirium. JAMA Netw Open. 2020 Apr 1;3(4):e203125. doi: 10.1001/jamanetworkopen.2020.3125.

Strutz PK, Kronzer V, Tzeng W, Arrington B, McKinnon SL, Ben Abdallah A, Haroutounian S, Avidan MS. The relationship between obstructive sleep apnoea and postoperative delirium and pain: an observational study of a surgical cohort. Anaesthesia. 2019 Dec;74(12):1542-1550. doi: 10.1111/anae.14855. Epub 2019 Sep 18.

King CR, Escallier KE, Ju YS, Lin N, Palanca BJ, McKinnon SL, Avidan MS. Obstructive sleep apnoea, positive airway pressure treatment and postoperative delirium: protocol for a retrospective observational study. BMJ Open. 2019 Aug 26;9(8):e026649. doi: 10.1136/bmjopen-2018-026649

Maybrier HR, King CR, Crawford AE, Mickle AM, Emmert DA, Wildes TS, Avidan MS, Palanca BJA; ENGAGES Study Investigators. Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium. J Clin Sleep Med. 2019 Jan 15;15(1):79-87. doi: 10.5664/jcsm.7576.

Lockhart EM, Willingham MD, Abdallah AB, Helsten DL, Bedair BA, Thomas J, Duntley S, Avidan MS. Obstructive sleep apnea screening and postoperative mortality in a large surgical cohort. Sleep Med. 2013 May;14(5):407-15. doi: 10.1016/j.sleep.2012.10.018. Epub 2013 Mar 13.

Basic Circadian Rhythm Mechanisms

Mazuski C, Abel JH, Chen SP, Hermanstyne TO, Jones JR, Simon T, Doyle FJ 3rd, Herzog ED. Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons. Neuron. 2018 Aug 8;99(3):555-563.e5. doi: 10.1016/j.neuron.2018.06.029. Epub 2018 Jul 12.

Tso CF, Simon T, Greenlaw AC, Puri T, Mieda M, Herzog ED. Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior. Curr Biol. 2017 Apr 3;27(7):1055-1061. doi: 10.1016/j.cub.2017.02.037. Epub 2017 Mar 23.

An S, Harang R, Meeker K, Granados-Fuentes D, Tsai CA, Mazuski C, Kim J, Doyle FJ 3rd, Petzold LR, Herzog ED. A neuropeptide speeds circadian entrainment by reducing intercellular synchrony. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4355-61. doi: 10.1073/pnas.1307088110. Epub 2013 Oct 28.

Freeman GM Jr, Krock RM, Aton SJ, Thaben P, Herzog ED. GABA networks destabilize genetic oscillations in the circadian pacemaker. Neuron. 2013 Jun 5;78(5):799-806. doi: 10.1016/j.neuron.2013.04.003.

Slat EA, Sponagel J, Marpegan L, Simon T, Kfoury N, Kim A, Binz A, Herzog ED, Rubin JB. Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma. J Biol Rhythms. 2017 Apr;32(2):121-129. doi: 10.1177/0748730417696788. Epub 2017 Mar 16.

Liang X, Ho MCW, Zhang Y, Li Y, Wu MN, Holy TE, Taghert PH. Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay. Neuron. 2019 May 22;102(4):843-857.e4. doi: 10.1016/j.neuron.2019.03.028. Epub 2019 Apr 10.

Liang X, Holy TE, Taghert PH. A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs. Neuron. 2017 Jun 21;94(6):1173-1189.e4. doi: 10.1016/j.neuron.2017.05.007.

Klose M, Duvall L, Li W, Liang X, Ren C, Steinbach JH, Taghert PH. Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation. Neuron. 2016 May 18;90(4):781-794. doi: 10.1016/j.neuron.2016.04.002.

Liang X, Holy TE, Taghert PH. Synchronous Drosophila circadian pacemakers display nonsynchronous Ca²⁺ rhythms in vivo. Science. 2016 Feb 26;351(6276):976-81. doi: 10.1126/science.aad3997

Ryzhikov M, Ehlers A, Steinberg D, Xie W, Oberlander E, Brown S, Gilmore PE, Townsend RR, Lane WS, Dolinay T, Nakahira K, Choi AMK, Haspel JA. Diurnal Rhythms Spatially and Temporally Organize Autophagy. Cell Rep. 2019 Feb 12;26(7):1880-1892.e6. doi: 10.1016/j.celrep.2019.01.072.

Obstetrics

McCarthy R, Martin-Fairey C, Sojka DK, Herzog ED, Jungheim ES, Stout MJ, Fay JC, Mahendroo M, Reese J, Herington JL, Plosa EJ, Shelton EL, England SK. Mouse models of preterm birth: suggested assessment and reporting guidelines. Biol Reprod. 2018 Nov 1;99(5):922-937. doi: 10.1093/biolre/ioy109.

Martin-Fairey CA, Zhao P, Wan L, Roenneberg T, Fay J, Ma X, McCarthy R, Jungheim ES, England SK, Herzog ED. Pregnancy Induces an Earlier Chronotype in Both Mice and Women. J Biol Rhythms. 2019 Jun;34(3):323-331. doi: 10.1177/0748730419844650. Epub 2019 Apr 24.

McCarthy R, Jungheim ES, Fay JC, Bates K, Herzog ED, England SK. Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time. Front Endocrinol (Lausanne). 2019 Sep 13;10:616. doi: 10.3389/fendo.2019.00616.

Critical Care/Pulmonology/Immunology

Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA. BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes. Mucosal Immunol. 2018 Jan;11(1):97-111. doi: 10.1038/mi.2017.24. Epub 2017 Apr 12.

Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast BJ, Reardon C, Shaw AC, Sengupta S, Szentirmai É, Thakkar M, Walker WE, Solt LA. Perfect timing: circadian rhythms, sleep, and immunity – an NIH workshop summary. JCI Insight. 2020 Jan 16;5(1):e131487. doi: 10.1172/jci.insight.131487.

Pediatrics

Licis AK, Vallorani A, Gao F, Chen C, Lenox J, Yamada KA, Duntley SP, Gutmann DH. Prevalence of Sleep Disturbances in Children With Neurofibromatosis Type 1. J Child Neurol. 2013 Nov;28(11):1400-1405. doi: 10.1177/0883073813500849.

Licis A. Sleep-Wake Disorders in Childhood. Continuum (Minneap Minn). 2020 Aug;26(4):1034-1069.

Licis A, Davis G, Eisenstein SA, Lugar HM, Hershey T. Sleep disturbances in Wolfram syndrome. Orphanet J Rare Dis. 2019 Aug 2;14(1):188. doi: 10.1186/s13023-019-1160-z.

Metabolism/Endocrinology

Yoshino J, Almeda-Valdes P, Patterson BW, Okunade AL, Imai S, Mittendorfer B, Klein S. Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. J Clin Endocrinol Metab. 2014 Sep;99(9):E1666-70. doi: 10.1210/jc.2014-1579. Epub 2014 May 30.

Magkos F, Smith GI, Reeds DN, Okunade A, Patterson BW, Mittendorfer B. One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. Obesity (Silver Spring). 2014 Feb;22(2):435-40. doi: 10.1002/oby.20562.

Psychiatry

Hoyniak CP, Whalen DJ, Barch D, Luby JL. Sleep problems in preschool-onset major depressive disorder: the effect of treatment with parent-child interaction therapy-emotion development. Eur Child Adolesc Psychiatry. 2020 Sep 15. doi: 10.1007/s00787-020-01641-1.

Whalen DJ, Gilbert KE, Barch DM, Luby JL, Belden AC. Variation in common preschool sleep problems as an early predictor for depression and anxiety symptom severity across time. J Child Psychol Psychiatry. 2017 Feb;58(2):151-159. doi: 10.1111/jcpp.12639. Epub 2016 Sep 12.

Neuroscience of Sleep

Tainton-Heap LA, Kirszenblat LC, Notaras ET, Grabowska MJ, Jeans R, Feng K, Shaw PJ, van Swinderen B. A Paradoxical Kind of Sleep in Drosophila melanogaster. Current Biology. 2020 Nov 24.

Melnattur K, Zhang B, Shaw PJ. Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila. Science Advances. 2020 May 1;6(19):eaaz2166.

Dissel S, Morgan E, Duong V, Chan D, van Swinderen B, Shaw P, Zars T. Sleep restores place learning to the adenylyl cyclase mutant rutabaga. Journal of neurogenetics. 2020 Jan 2;34(1):83-91.

Melnattur K, Shaw P. Staying awake to stay alive: A circuit controlling starvation-induced waking. PLoS biology. 2019 Mar 27;17(3):e3000199.

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