Biomarkers of Alzheimer Disease in Sleep and EEG

The goal of this study is to develop sleep and EEG (brain wave) biomarkers of early Alzheimer Disease, to use for non-invasive screening, even prior to cognitive symptoms.

We are actively enrolling participants at least 65 years of age, who have normal memory or mild problems with memory. The study involves memory tests, sleep studies at home and at the Washington University medical campus, and a lumbar puncture. Participants will be reimbursed for their time and effort.

[In collaboration with Miranda Lim MD PhD]

Principal Investigator: Yo-El Ju, MD
Coordinator: Jill Boyd

NAPS Consortium

North American Prodromal Synucleinopathy Consortium for REM sleep behavior disorder

The NAPS Consortium is enrolling participants with REM sleep behavior disorder (RBD), in order to form a trial-ready cohort for future neuroprotective treatment clinical trials. Washington University is the lead site for the 10 NAPS Consortium sites in the US and Canada. Please visit the NAPS Consortium website for additional details.

Principal Investigator: Yo-El Ju, MD
Coordinator: Maggie Zangrilli

Sleep and Circadian Rhythms in Alzheimer Disease

“Sleep & Tau” study

There is a bi-directional relationship between sleep/circadian dysfunction and Alzheimer Disease pathology. In this study, we will tease apart this chicken-and-egg relationship by re-measuring sleep in individuals who participated in the Knight ADRC Actigraphy Wave 1 study in 2010-2012. Contact or call us if you are interested in participating.

[In collaboration with David Holtzman MD, Erik Musiek MD PhD]

Principal Investigator: Yo-El Ju, MD
Coordinator: Maggie Zangrilli